| Area Code | 573 |
| State | Missouri |
| Current Time in Area Code 573 | 573> CDT |
| Timezone | Central Daylight Time |
| Regional Market Area | Columbia-Jefferson City Area Metro St. Louis Paducah-Cape Girardeau-Harrisburg-Mt Vernon Area Quincy-Hannibal-Keokuk Springfield MO Area |
| Metro Area(s) | Cape Girardeau, MO-IL Columbia, MO Farmington, MO Fort Leonard Wood, MO Hannibal, MO Jefferson City, MO Kennett, MO Mexico, MO Poplar Bluff, MO Rolla, MO Sikeston, MO |
| Population (2020) | 1154683 |
| Adjacent Area Codes | 217,270,327,364,417,447,618,636,660,730,731,870 |
| Cape Girardeau |
| Columbia |
| Jefferson City |