| Place Name | Holy Cross |
| Place Type | City |
| ZIP Code(s) | 52053 |
| County | Dubuque County |
| Area Code(s) | 563 |
| Timezone | Central Daylight Time (CDT) |
| Population (2022) | 373 |
| Population Growth Rate (2010-19) | -4.81% |
| Majority Ethnicity | White 93.67% |
| Metro/Micro Stats Area | Dubuque, IA |
| US Congressional District(s) | Iowa 1st |
| State House Districts | 57 |
| State Senate Districts | 29 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 93.67% |
| African American | 0% |
| Hispanic | 2.53% |
| Asian | 0% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 3.8% |