This table ranks all 31 ZIP codes in the Columbia, MO MSA by estimated 2022 population, from highest to lowest.
| # | ZIP Code | Place Name | Population (2022) |
|---|---|---|---|
| 1 | ZIP 65203 | Columbia | 59,673 |
| 2 | ZIP 65201 | Columbia | 48,537 |
| 3 | ZIP 65202 | Columbia | 47,776 |
| 4 | ZIP 65233 | Boonville | 10,903 |
| 5 | ZIP 65240 | Centralia | 8,640 |
| 6 | ZIP 65018 | California | 7,834 |
| 7 | ZIP 65010 | Ashland | 6,970 |
| 8 | ZIP 65255 | Hallsville | 5,112 |
| 9 | ZIP 65248 | Fayette | 4,372 |
| 10 | ZIP 65081 | Tipton | 4,343 |
| 11 | ZIP 65039 | Hartsburg | 2,867 |
| 12 | ZIP 65243 | Clark | 2,690 |
| 13 | ZIP 65284 | Sturgeon | 2,107 |
| 14 | ZIP 65256 | Harrisburg | 1,907 |
| 15 | ZIP 65254 | Glasgow | 1,904 |
| 16 | ZIP 65274 | New Franklin | 1,901 |
| 17 | ZIP 65276 | Pilot Grove | 1,794 |
| 18 | ZIP 65257 | Higbee | 1,770 |
| 19 | ZIP 65279 | Rocheport | 1,519 |
| 20 | ZIP 65348 | Otterville | 1,255 |
| 21 | ZIP 65237 | Bunceton | 937 |
| 22 | ZIP 65347 | Nelson | 892 |
| 23 | ZIP 65068 | Prairie Home | 859 |
| 24 | ZIP 65025 | Clarksburg | 777 |
| 25 | ZIP 65322 | Blackwater | 655 |
| 26 | ZIP 65250 | Franklin | 508 |
| 27 | ZIP 65354 | Syracuse | 490 |
| 28 | ZIP 65230 | Armstrong | 471 |
| 29 | ZIP 65215 | Columbia | 266 |
| 30 | ZIP 65287 | Wooldridge | 262 |
| 31 | ZIP 65216 | Columbia | 180 |