This table ranks all 19 ZIP codes in the Florence, SC MSA by estimated 2022 population, from highest to lowest.
| # | ZIP Code | Place Name | Population (2022) |
|---|---|---|---|
| 1 | ZIP 29501 | Florence | 47,406 |
| 2 | ZIP 29550 | Hartsville | 29,776 |
| 3 | ZIP 29505 | Florence | 24,562 |
| 4 | ZIP 29506 | Florence | 20,545 |
| 5 | ZIP 29532 | Darlington | 20,000 |
| 6 | ZIP 29560 | Lake City | 12,073 |
| 7 | ZIP 29161 | Timmonsville | 10,935 |
| 8 | ZIP 29541 | Effingham | 9,836 |
| 9 | ZIP 29554 | Hemingway | 8,930 |
| 10 | ZIP 29555 | Johnsonville | 6,043 |
| 11 | ZIP 29583 | Pamplico | 5,074 |
| 12 | ZIP 29591 | Scranton | 4,565 |
| 13 | ZIP 29069 | Lamar | 4,460 |
| 14 | ZIP 29540 | Darlington | 4,419 |
| 15 | ZIP 29530 | Coward | 2,597 |
| 16 | ZIP 29101 | McBee | 2,592 |
| 17 | ZIP 29593 | Society Hill | 1,990 |
| 18 | ZIP 29114 | Olanta | 1,459 |
| 19 | ZIP 29079 | Lydia | 14 |