This table ranks all 17 ZIP codes in the Hannibal, MO MSA by estimated 2022 population, from highest to lowest.
| # | ZIP Code | Place Name | Population (2022) |
|---|---|---|---|
| 1 | ZIP 63401 | Hannibal | 21,167 |
| 2 | ZIP 63461 | Palmyra | 5,452 |
| 3 | ZIP 63456 | Monroe City | 4,995 |
| 4 | ZIP 63459 | New London | 4,523 |
| 5 | ZIP 63382 | Vandalia | 4,167 |
| 6 | ZIP 63462 | Perry | 1,461 |
| 7 | ZIP 63436 | Center | 1,266 |
| 8 | ZIP 63454 | Maywood | 1,166 |
| 9 | ZIP 63352 | Laddonia | 1,150 |
| 10 | ZIP 63441 | Frankford | 1,114 |
| 11 | ZIP 63440 | Ewing | 1,012 |
| 12 | ZIP 63463 | Philadelphia | 825 |
| 13 | ZIP 63471 | Taylor | 805 |
| 14 | ZIP 63443 | Hunnewell | 305 |
| 15 | ZIP 63438 | Durham | 232 |
| 16 | ZIP 63439 | Emden | 174 |
| 17 | ZIP 63467 | Saverton | 77 |