This table ranks all 10 ZIP codes in the Key West, FL MSA by estimated 2022 population, from highest to lowest.
| # | ZIP Code | Place Name | Population (2022) |
|---|---|---|---|
| 1 | ZIP 33040 | Key West | 36,379 |
| 2 | ZIP 33034 | Homestead | 23,774 |
| 3 | ZIP 33037 | Key Largo | 13,265 |
| 4 | ZIP 33050 | Marathon | 10,520 |
| 5 | ZIP 33042 | Summerland Key | 6,990 |
| 6 | ZIP 33070 | Tavernier | 5,717 |
| 7 | ZIP 33043 | Big Pine Key | 4,547 |
| 8 | ZIP 33036 | Islamorada | 3,620 |
| 9 | ZIP 33051 | Key Colony Beach | 650 |
| 10 | ZIP 33001 | Long Key | 340 |