| District Name | Karnes City Independent School District |
| State | Texas |
| County | Karnes County Atascosa County |
| Statistical Area | San Antonio-New Braunfels, TX |
| Cities/Towns | Karnes City |
| Total Students (2021) | 1315 |
| District Growth Rate (2017-21) | 22.7% |
| Majority Race/Ethnicty | Hispanic (64.6%) |
| Free/Reduced Lunch Program | 68.97% |