| District Name | Santa Fe Independent School District |
| State | Texas |
| County | Galveston County |
| Statistical Area | Houston-The Woodlands-Sugar Land, TX |
| Total Students (2021) | 4343 |
| District Growth Rate (2017-21) | -9.0% |
| Majority Race/Ethnicty | White (72.0%) |
| Free/Reduced Lunch Program | 49.57% |