| District Name | Santa Maria Independent School District |
| State | Texas |
| County | Cameron County |
| Statistical Area | Brownsville-Harlingen, TX |
| Total Students (2021) | 604 |
| District Growth Rate (2017-21) | -12.5% |
| Majority Race/Ethnicty | Hispanic (98.5%) |
| Free/Reduced Lunch Program | 98.34% |