This table ranks all 23 ZIP codes in the Orangeburg, SC MSA by estimated 2022 population, from highest to lowest.
| # | ZIP Code | Place Name | Population (2022) |
|---|---|---|---|
| 1 | ZIP 29115 | Orangeburg | 27,024 |
| 2 | ZIP 29118 | Orangeburg | 16,051 |
| 3 | ZIP 29135 | Saint Matthews | 7,974 |
| 4 | ZIP 29477 | Saint George | 7,195 |
| 5 | ZIP 29059 | Holly Hill | 5,258 |
| 6 | ZIP 29142 | Santee | 4,907 |
| 7 | ZIP 29048 | Eutawville | 4,820 |
| 8 | ZIP 29436 | Cross | 3,992 |
| 9 | ZIP 29112 | North | 3,627 |
| 10 | ZIP 29047 | Elloree | 3,490 |
| 11 | ZIP 29018 | Bowman | 3,359 |
| 12 | ZIP 29039 | Cordova | 3,058 |
| 13 | ZIP 29107 | Neeses | 2,709 |
| 14 | ZIP 29038 | Cope | 2,691 |
| 15 | ZIP 29432 | Branchville | 2,389 |
| 16 | ZIP 29137 | Salley | 2,335 |
| 17 | ZIP 29113 | Norway | 2,215 |
| 18 | ZIP 29030 | Cameron | 2,059 |
| 19 | ZIP 29163 | Vance | 1,385 |
| 20 | ZIP 29146 | Springfield | 1,267 |
| 21 | ZIP 29471 | Reevesville | 1,044 |
| 22 | ZIP 29133 | Rowesville | 909 |
| 23 | ZIP 29117 | Orangeburg | 555 |